Neuroscience, 2016-10, Vol.334, p.148-159
2016
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex
- Ist Teil von
- Neuroscience, 2016-10, Vol.334, p.148-159
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • LC facilitates rather than inhibits CCI-ION neuropathic pain 8 weeks post injury. • Anti-DβH-saporin elimination of noradrenergic LC neurons reduces hypersensitivity. • Excitatory GABAA signaling and LC are pain generators facilitating hypersensitivity. • Facilitation is mediated by NAα1 not NAα2 receptors in the medial prefrontal cortex. • Transcription factor ATF3 expression is increased 8 weeks after CCI-ION injury.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2016.08.005Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5367623
- Format
- –
- Schlagworte
- Activating Transcription Factor 3 - metabolism, Adrenergic alpha-Antagonists - pharmacology, Adrenergic Neurons - drug effects, Adrenergic Neurons - metabolism, Animals, anti-DβH-saporin, Bicuculline - pharmacology, CCI-ION, chronic orofacial neuropathic pain, Chronic Pain - drug therapy, Chronic Pain - metabolism, Disease Models, Animal, dopamine-beta-hydroxylase, Facial Pain - drug therapy, Facial Pain - metabolism, GABA-A Receptor Antagonists - pharmacology, Hyperalgesia - drug therapy, Hyperalgesia - metabolism, Idazoxan - pharmacology, Locus Coeruleus - drug effects, Locus Coeruleus - metabolism, Male, mechanical allodynia, Neuralgia - drug therapy, Neuralgia - metabolism, Neurology, Oxathiins - pharmacology, Prefrontal Cortex - drug effects, Prefrontal Cortex - metabolism, Rats, Sprague-Dawley, Receptors, Adrenergic, alpha-1 - metabolism, Receptors, Adrenergic, alpha-2 - metabolism, Receptors, GABA-A - metabolism, spinal trigeminal caudalis, Trigeminal Nerve Injuries - drug therapy, Trigeminal Nerve Injuries - metabolism