Details
- Autor(en) / Beteiligte
- Titel
- Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation
- Ist Teil von
- Oncology reports, 2017-02, Vol.37 (2), p.754-760
- Ort / Verlag
- Greece: D.A. Spandidos
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- It is well documented that A proliferation-inducing ligand (APRIL), a member of the tumor necrosis factor superfamily, plays a crucial role in the occurrence and development of tumors. In the present study, we evaluated the synergistic effect of APRIL knockdown and Jiedu Xiaozheng Yin (JXY), a Traditional Chinese Medicinal recipe, on the inhibition of hepatocellular carcinoma (HCC) cell proliferation and elucidated the underlying mechanism. The results demonstrated that both APRIL knockdown using small interfering RNA (siRNA) and JXY treatment could trigger cell cycle arrest and cell apoptosis, and suppress HCC cell proliferation through an NF-κB-related pathway. Synergism was further demonstrated between APRIL knockdown and JXY treatment. In conclusion, these results indicate that APRIL is a target gene for HCC and combination of siRNA-APRIL and JXY application holds great promise as a novel approach for the treatment of APRIL-positive HCC.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1021-335XeISSN: 1791-2431DOI: 10.3892/or.2016.5339Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5355738
- Format
- –
- Schlagworte
- A proliferation-inducing ligand, Animals, Apoptosis, Apoptosis - drug effects, Apoptosis - genetics, Blotting, Western, Cancer therapies, Carcinoma, Hepatocellular - drug therapy, Carcinoma, Hepatocellular - genetics, Carcinoma, Hepatocellular - pathology, Care and treatment, Cell cycle, Cell growth, Cell Proliferation - drug effects, Cell Proliferation - genetics, Cellular proteins, Chinese medicine, Combined Modality Therapy, Development and progression, Drugs, Chinese Herbal - chemistry, Genes, Genetic aspects, Health aspects, hepatocellular carcinoma, Hepatoma, Herbal medicine, Humans, Immunoglobulins, Jiedu Xiaozheng Yin, Ligands, Liver cancer, Liver Neoplasms - drug therapy, Liver Neoplasms - genetics, Liver Neoplasms - pathology, Male, Medicine, Chinese, Membranes, Metastasis, Methods, Mice, nuclear factor-κB, Patient outcomes, Plant Extracts - pharmacology, Proteins, Rats, Rats, Sprague-Dawley, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - genetics, RNA, Small Interfering - genetics, Rodents, Studies, Tumor Cells, Cultured, Tumor Necrosis Factor Ligand Superfamily Member 13 - antagonists & inhibitors, Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics, Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism, Tumor necrosis factor-TNF, Tumorigenesis, Tumors, Vascular endothelial growth factor, Xenograft Model Antitumor Assays