Details

Autor(en) / Beteiligte

• Vincent, Maxence S
• Canestrari, Mickaël J
• Leone, Philippe
• Stathopulos, Julien
• Ize, Bérengère
• Zoued, Abdelrahim
• Cambillau, Christian
• Kellenberger, Christine
• Roussel, Alain
• Cascales, Eric

Titel

Characterization of the Porphyromonas gingivalis Type IX Secretion Trans-envelope PorKLMNP Core Complex

Ist Teil von

• The Journal of biological chemistry, 2017-02, Vol.292 (8), p.3252-3261

Ort / Verlag

United States: American Society for Biochemistry and Molecular Biology

Erscheinungsjahr

2017

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The transport of proteins at the cell surface of Bacteroidetes depends on a secretory apparatus known as type IX secretion system (T9SS). This machine is responsible for the cell surface exposition of various proteins, such as adhesins, required for gliding motility in , S-layer components in , and tooth tissue-degrading enzymes in the oral pathogen Although a number of subunits of the T9SS have been identified, we lack details on the architecture of this secretion apparatus. Here we provide evidence that five of the genes encoding the core complex of the T9SS are co-transcribed and that the gene products are distributed in the cell envelope. Protein-protein interaction studies then revealed that these proteins oligomerize and interact through a dense network of contacts.