Gastroenterology clinics of North America, 2017-03, Vol.46 (1), p.155-169
2017
Details
- Autor(en) / Beteiligte
- Titel
- Gut Microbiota and Complications of Liver Disease
- Ist Teil von
- Gastroenterology clinics of North America, 2017-03, Vol.46 (1), p.155-169
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chronic liver disease, cirrhosis, and its complications are epidemic worldwide. Most complications are mediated through a dysfunctional gut-liver axis. New techniques have made culture-independent analysis of the gut microbiome widespread. With insight into an unfavorable microbiome (dysbiosis) and how it affects liver disease, investigators have discovered new targets to potentially improve outcomes. Dysbiosis is associated with endotoxemia and propagates liver injury due to nonalcoholic steatohepatitis and alcohol. The composition and functionality of the microbiome changes with the development of cirrhosis, decompensation, and with treatments for these conditions. Gut microbiota can be used to predict clinically relevant outcomes in cirrhosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-8553eISSN: 1558-1942DOI: 10.1016/j.gtc.2016.09.013Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5300079
- Format
- –
- Schlagworte
- Alcoholic liver disease, Bacteroidetes, Bile acids, Chronic Disease, Cirrhosis, Dysbiosis, Dysbiosis - complications, Dysbiosis - physiopathology, Firmicutes, Gastroenterology and Hepatology, Gastrointestinal Microbiome, Hepatic Encephalopathy - microbiology, Humans, Intestinal Mucosa - microbiology, Intestinal Mucosa - physiopathology, Liver Cirrhosis - etiology, Liver Diseases, Alcoholic - complications, Liver Diseases, Alcoholic - microbiology, Microbiome, Non-alcoholic Fatty Liver Disease - complications, Non-alcoholic Fatty Liver Disease - microbiology, Nonalcoholic steatohepatitis