Critical care clinics, 2015-10, Vol.31 (4), p.661-674
2015
Details
- Autor(en) / Beteiligte
- Titel
- Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury
- Ist Teil von
- Critical care clinics, 2015-10, Vol.31 (4), p.661-674
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Thrombocytopenia-associated multiple organ failure (TAMOF) is a clinical phenotype that encompasses a spectrum of syndromes associated with disseminated microvascular thromboses, such as the thrombotic microangiopathies thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) and disseminated intravascular coagulation (DIC). Autopsies findings in TTP, HUS, or DIC reveal specific findings that can differentiate these 3 entities. Von Willebrand factor and ADAMTS-13 play a central role in TTP. Shiga toxins and the complement pathway are vital in the development of HUS. Tissue factor is the major protease that drives the pathology of DIC. Acute kidney injury (AKI) is a common feature in patients with TAMOF.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0749-0704eISSN: 1557-8232DOI: 10.1016/j.ccc.2015.06.004Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5281060
- Format
- –
- Schlagworte
- Acute Kidney Injury - etiology, Acute Kidney Injury - metabolism, ADAM Proteins - blood, ADAM Proteins - genetics, ADAMTS-13, ADAMTS13 Protein, AKI, Antibodies, Monoclonal, Humanized - therapeutic use, Complement Inactivating Agents - therapeutic use, Complement System Proteins - metabolism, Critical Care, DIC, Disseminated Intravascular Coagulation - complications, Disseminated Intravascular Coagulation - metabolism, Disseminated Intravascular Coagulation - therapy, Hemolytic-Uremic Syndrome - complications, Hemolytic-Uremic Syndrome - genetics, Hemolytic-Uremic Syndrome - microbiology, Hemolytic-Uremic Syndrome - therapy, Humans, HUS, Multiple Organ Failure - etiology, Multiple Organ Failure - metabolism, Multiple Organ Failure - therapy, Platelet, Purpura, Thrombotic Thrombocytopenic - complications, Purpura, Thrombotic Thrombocytopenic - genetics, Purpura, Thrombotic Thrombocytopenic - metabolism, Purpura, Thrombotic Thrombocytopenic - therapy, Shiga Toxins - metabolism, TAMOF, Thromboplastin - metabolism, TTP, von Willebrand Factor - genetics, von Willebrand Factor - metabolism, VWF