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Autor(en) / Beteiligte
Titel
Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation
Ist Teil von
  • Oncotarget, 2016-07, Vol.7 (29), p.46419-46432
Ort / Verlag
United States: Impact Journals LLC
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
  • Despite advancing therapies, thousands of women die every year of breast cancer. Myosins, actin-dependent molecular motors, are likely to contribute to tumor formation and metastasis via their effects on cell adhesion and migration and may provide promising new targets for cancer therapies. Using the MMTV-PyMT murine model of breast cancer, we identified Myosin 1e (MYO1E) as a novel tumor promoter. Tumor latency in mice lacking MYO1E was significantly increased, and tumors formed in the absence of MYO1E displayed unusual papillary morphology, with well-differentiated layers of epithelial cells covering fibrovascular cores, rather than solid sheets of tumor cells typically observed in this cancer model. These tumors were reminiscent of papillary breast cancer in humans that is typically non-invasive and often cured by tumor excision. MYO1E-null tumors exhibited decreased expression of the markers of cell proliferation, which was recapitulated in primary tumor cells derived from MYO1E-null mice. In agreement with our findings, meta-analysis of patient survival data indicated that MYO1E expression level was associated with reduced recurrence-free survival in basal-like breast cancer. Overall, our data suggests that MYO1E contributes to breast tumor malignancy and regulates the differentiation and proliferation state of breast tumor cells.
Sprache
Englisch
Identifikatoren
ISSN: 1949-2553
eISSN: 1949-2553
DOI: 10.18632/oncotarget.10139
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5216807

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