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A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation
Ist Teil von
The New England journal of medicine, 2016-10, Vol.375 (17), p.1617-1627
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
In this trial, long-term supplemental oxygen treatment did not result in longer survival than no use of supplemental oxygen among patients with stable COPD and moderate resting desaturation (Spo2, 89 to 93%) or moderate exercise-induced desaturation.
Two trials that were conducted in the 1970s showed that long-term treatment with supplemental oxygen reduced mortality among patients with chronic obstructive pulmonary disease (COPD) and severe resting hypoxemia.
1
,
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These results led to the recommendation that supplemental oxygen be administered to patients with an oxyhemoglobin saturation, as measured by pulse oximetry (Spo
2
), of less than 89%.
3
,
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In the 1990s, two trials evaluated long-term treatment with supplemental oxygen in patients with COPD who had mild-to-moderate daytime hypoxemia; neither trial showed a mortality benefit, but both were underpowered to assess mortality.
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,
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The effects of oxygen treatment on . . .