Details

Autor(en) / Beteiligte

• Albert, Richard K
• Au, David H
• Blackford, Amanda L
• Casaburi, Richard
• Cooper, Jr, J Allen
• Criner, Gerard J
• Diaz, Philip
• Fuhlbrigge, Anne L
• Gay, Steven E
• Kanner, Richard E
• MacIntyre, Neil
• Martinez, Fernando J
• Panos, Ralph J
• Piantadosi, Steven
• Sciurba, Frank
• Shade, David
• Stibolt, Thomas
• Stoller, James K
• Wise, Robert
• Yusen, Roger D
• Tonascia, James
• Sternberg, Alice L
• Bailey, William

Titel

A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation

Ist Teil von

• The New England journal of medicine, 2016-10, Vol.375 (17), p.1617-1627

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In this trial, long-term supplemental oxygen treatment did not result in longer survival than no use of supplemental oxygen among patients with stable COPD and moderate resting desaturation (Spo2, 89 to 93%) or moderate exercise-induced desaturation. Two trials that were conducted in the 1970s showed that long-term treatment with supplemental oxygen reduced mortality among patients with chronic obstructive pulmonary disease (COPD) and severe resting hypoxemia. 1 , 2 These results led to the recommendation that supplemental oxygen be administered to patients with an oxyhemoglobin saturation, as measured by pulse oximetry (Spo 2 ), of less than 89%. 3 , 4 In the 1990s, two trials evaluated long-term treatment with supplemental oxygen in patients with COPD who had mild-to-moderate daytime hypoxemia; neither trial showed a mortality benefit, but both were underpowered to assess mortality. 5 , 6 The effects of oxygen treatment on . . .