Journal of allergy and clinical immunology, 2016-12, Vol.138 (6), p.1556-1558
2016
Details
- Autor(en) / Beteiligte
- Titel
- Asthma in Puerto Ricans: lessons from a high-risk population
- Ist Teil von
- Journal of allergy and clinical immunology, 2016-12, Vol.138 (6), p.1556-1558
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- In a study of Puerto Rican school-aged children, exposure to violence was associated with methylation of the promoter of ADCYAP1R1, which was in turn associated with asthma. [...]an ADCYAP1R1 SNP was associated with asthma in Puerto Rican children.9 Chronic stress has also been associated with reduced expression of the gene for the β2-adrenergic receptor (ADRB2, key for bronchodilator response [BDR]) in WBCs of patients with asthma.10 Interestingly, Puerto Ricans have reduced BDR,11 raising the possibility that chronic stress leads to asthma morbidity through downregulation of ADRB2.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0091-6749eISSN: 1097-6825DOI: 10.1016/j.jaci.2016.08.047Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5189666
- Format
- –
- Schlagworte
- Air pollution, Allergy and Immunology, Asthma, Clinical trials, Epigenetics, Genealogy, Genomes, Health risk assessment, high risk, Hispanic people, Minority & ethnic groups, Morbidity, Mortality, multifactorial, Obesity, Outdoor air quality, Public health, Puerto Ricans, Smoking, Stress, Studies, Violence