Details

Autor(en) / Beteiligte

• Benigni, Ariela
• Gagliardini, Elena
• Remuzzi, Giuseppe
• Alachkar, Nada
• Carter-Monroe, Naima
• Reiser, Jochen
• Greka, Anna
• Weins, Astrid
• Mundel, Peter

Titel

Abatacept in B7-1–Positive Proteinuric Kidney Disease

Ist Teil von

• The New England journal of medicine, 2014-03, Vol.370 (13), p.1261-1266

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• To the Editor: In their Brief Report, Yu et al. (Dec. 19 issue) 1 describe the use of abatacept, an inhibitor of the T-cell costimulatory molecule B7-1, in inducing remission in five patients with focal segmental glomerulosclerosis (FSGS) resistant to rituximab and glucocorticoids (one patient with primary FSGS and four with recurrent FSGS after transplantation). The rationale for using abatacept was that B7-1 is induced in podocytes in primary and recurrent FSGS as well as in patients with membranous nephropathy. In an attempt to reproduce their findings with the same antibodies, we found no B7-1 signal in samples obtained from patients . . .