Details

Autor(en) / Beteiligte

• Park, Sung Il
• Shin, Gunchul
• McCall, Jordan G.
• Al-Hasani, Ream
• Norris, Aaron
• Xia, Li
• Brenner, Daniel S.
• Noh, Kyung Nim
• Bang, Sang Yun
• Bhatti, Dionnet L.
• Jang, Kyung-In
• Kang, Seung-Kyun
• Mickle, Aaron D.
• Dussor, Gregory
• Price, Theodore J.
• Gereau, Robert W.
• Bruchas, Michael R.
• Rogers, John A.

Titel

Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (50), p.E8169-E8177

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Optogenetic methods to modulate cells and signaling pathways via targeted expression and activation of light-sensitive proteins have greatly accelerated the process of mapping complex neural circuits and defining their roles in physiological and pathological contexts. Recently demonstrated technologies based on injectable, microscale inorganic light-emitting diodes (μ-ILEDs) with wireless control and power delivery strategies offer important functionality in such experiments, by eliminating the external tethers associated with traditional fiber optic approaches. Existing wireless μ-ILED embodiments allow, however, illumination only at a single targeted region of the brain with a single optical wavelength and over spatial ranges of operation that are constrained by the radio frequency power transmission hardware. Here we report stretchable, multiresonance antennas and battery-free schemes for multichannel wireless operation of independently addressable, multicolor μ-ILEDs with fully implantable, miniaturized platforms. This advance, as demonstrated through in vitro and in vivo studies using thin, mechanically soft systems that separately control as many as three different μ-ILEDs, relies on specially designed stretchable antennas in which parallel capacitive coupling circuits yield several independent, well-separated operating frequencies, as verified through experimental and modeling results. When used in combination with active motion-tracking antenna arrays, these devices enable multichannel optogenetic research on complex behavioral responses in groups of animals over large areas at low levels of radio frequency power (<1 W). Studies of the regions of the brain that are involved in sleep arousal (locus coeruleus) and preference/aversion (nucleus accumbens) demonstrate the unique capabilities of these technologies.