Details

Autor(en) / Beteiligte

• Quicke, Kendra M.
• Bowen, James R.
• Johnson, Erica L.
• McDonald, Circe E.
• Ma, Huailiang
• O’Neal, Justin T.
• Rajakumar, Augustine
• Wrammert, Jens
• Rimawi, Bassam H.
• Pulendran, Bali
• Schinazi, Raymond F.
• Chakraborty, Rana
• Suthar, Mehul S.

Titel

Zika Virus Infects Human Placental Macrophages

Ist Teil von

• Cell host & microbe, 2016-07, Vol.20 (1), p.83-90

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The recent Zika virus (ZIKV) outbreak in Brazil has been directly linked to increased cases of microcephaly in newborns. Current evidence indicates that ZIKV is transmitted vertically from mother to fetus. However, the mechanism of intrauterine transmission and the cell types involved remain unknown. We demonstrate that the contemporary ZIKV strain PRVABC59 (PR 2015) infects and replicates in primary human placental macrophages, called Hofbauer cells, and to a lesser extent in cytotrophoblasts, isolated from villous tissue of full-term placentae. Viral replication coincides with induction of type I interferon (IFN), pro-inflammatory cytokines, and antiviral gene expression, but with minimal cell death. Our results suggest a mechanism for intrauterine transmission in which ZIKV gains access to the fetal compartment by directly infecting placental cells and disrupting the placental barrier. [Display omitted] •Zika virus (ZIKV) infects and replicates in primary human placental macrophages•ZIKV also infects human placental cytotrophoblasts, but with delayed replication kinetics•ZIKV replication coincides with IFN and antiviral gene induction, but minimal cell death The currently circulating Zika virus strain is directly linked to fetal microcephaly. However, the mechanism of intrauterine ZIKV transmission is unknown. Quicke et al. demonstrate that a contemporary ZIKV strain infects and replicates in primary human placental macrophages and cytotrophoblasts, suggesting a route for ZIKV to cross the placental barrier.