Details

Autor(en) / Beteiligte

• Park, Yongho
• Schindler, Corinna S
• Jacobsen, Eric N

Titel

Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H‑Bond Donor and Lewis Base

Ist Teil von

• Journal of the American Chemical Society, 2016-11, Vol.138 (45), p.14848-14851

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An enantioselective, catalytic aza-Sakurai cyclization of chlorolactams has been developed as an efficient entry into indolizidine and quinolizidine frameworks. Structure–enantioselectivity relationship studies and mechanistic analysis point to a dual role of the catalyst wherein the thiourea moiety of the catalyst is engaged in both anion binding and Lewis base activation of a substrate.