Details

Autor(en) / Beteiligte

• Willeit, Peter
• Skroblin, Philipp
• Kiechl, Stefan
• Fernández-Hernando, Carlos
• Mayr, Manuel

Titel

Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?

Ist Teil von

• European heart journal, 2016-11, Vol.37 (43), p.3260-3266

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Recent discoveries have revealed that microRNAs (miRNAs) play a key role in the regulation of gene expression. In this review, we summarize the rapidly evolving knowledge about liver miRNAs (including miR-33, -33*, miR-223, -30c, -144, -148a, -24, -29, and -122) and their link to hepatic lipid metabolism, atherosclerosis and cardiovascular disease, non-alcoholic fatty liver disease, metabolic syndrome, and type-2 diabetes. With regards to its biomarker potential, the main focus is on miR-122 as the most abundant liver miRNA with exquisite tissue specificity. MiR-122 has been proposed to play a central role in the maintenance of lipid and glucose homeostasis and is consistently detectable in serum and plasma. This miRNA may therefore constitute a novel biomarker for cardiovascular and metabolic diseases.