Details

Autor(en) / Beteiligte

• Yu, Guocan
• Cook, Timothy R.
• Li, Yang
• Yan, Xuzhou
• Wu, Dan
• Shao, Li
• Shen, Jie
• Tang, Guping
• Huang, Feihe
• Chen, Xiaoyuan
• Stang, Peter J.

Titel

Tetraphenylethene-based highly emissive metallacage as a component of theranostic supramolecular nanoparticles

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (48), p.13720-13725

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2016

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A theranostic agent combines diagnostic reporter with therapeutic activity in a single entity, an approach that seeks to increase the efficacy of cancer treatment. Herein, we describe the synthesis of a highly emissive tetraphenylethene-based metallacage using multicomponent coordination-driven self-assembly that exhibits a coordination-triggered aggregation-induced emission (AIE) enhancement. The formation of metallacage-loaded nanoparticles (MNPs) occurs when the assembly is treated with two variants of a 1,2-distearoyl-phosphatidylethanolamine (DSPE)/polyethylene glycol (PEG) conjugate, mPEG-DSPE, and biotin-PEG-DSPE. This combination endows the resultant MNPs with excellent stability and targeting ability, specifically enabling selective delivery of the metallacages to cancer cells that overexpress biotin receptors via receptor-mediated endocytosis. Although the mechanism of activity is based on existing Pt(II) anticancer drugs such as oxaliplatin, carboplatin, and cisplatin, in vitro and in vivo studies indicate that the MNPs are more active and show low systemic activity while also possessing emissive properties that allow for fluorescence-based imaging. This pioneering example of a metallacage that combines biologically active components with AIE imaging establishes supramolecular coordination complexes imbedded within nanoparticles as a promising potential theranostic platform for cancer treatment.