Details

Autor(en) / Beteiligte

• Donovan, Jenny L
• Hamdy, Freddie C
• Lane, J. Athene
• Mason, Malcolm
• Metcalfe, Chris
• Walsh, Eleanor
• Blazeby, Jane M
• Peters, Tim J
• Holding, Peter
• Bonnington, Susan
• Lennon, Teresa
• Bradshaw, Lynne
• Cooper, Deborah
• Herbert, Phillipa
• Howson, Joanne
• Jones, Amanda
• Lyons, Norma
• Salter, Elizabeth
• Thompson, Pauline
• Tidball, Sarah
• Blaikie, Jan
• Gray, Catherine
• Bollina, Prasad
• Catto, James
• Doble, Andrew
• Doherty, Alan
• Gillatt, David
• Kockelbergh, Roger
• Kynaston, Howard
• Paul, Alan
• Powell, Philip
• Prescott, Stephen
• Rosario, Derek J
• Rowe, Edward
• Davis, Michael
• Turner, Emma L
• Martin, Richard M
• Neal, David E

Titel

Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

Ist Teil von

• The New England journal of medicine, 2016-10, Vol.375 (15), p.1425-1437

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The choice of treatment for PSA-detected, localized prostate cancer is influenced by effects of the interventions on quality of life. In the ProtecT trial, patterns of side-effect severity, improvement, and decline in urinary, sexual, and bowel function differed among the treatments. As reported in a companion article in the Journal, the U.K. National Institute for Health Research–supported Prostate Testing for Cancer and Treatment (ProtecT) trial has shown no significant difference in prostate-cancer–specific mortality or all-cause mortality among men with prostate cancer detected by prostate-specific antigen (PSA) testing who were randomly assigned to radical prostatectomy, active monitoring (a surveillance strategy), or radical conformal radiotherapy with neoadjuvant hormonal therapy, at a median of 10 years of follow-up; however, the ProtecT trial has shown higher rates of metastases and disease progression among men in the active-monitoring group than among men in the radical-treatment groups. . . .