Details

Autor(en) / Beteiligte

• Coşkun, E
• Zengin, O
• Kenan, S
• Kimyon, G
• Erdogan Er, K
• Okumus, S
• Mesut Onat, A
• Erbagcı, I
• Kısacık, B

Titel

Evaluation of choroidal thickness in patients with scleroderma

Ist Teil von

• Eye (London), 2016-04, Vol.30 (4), p.588-592

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose To investigate the choroidal thickness in patients with scleroderma and to compare them with healthy control subjects. Methods Forty-six patients with scleroderma (3 male and 43 female) and 31 healthy controls (6 male and 25 female) were included in the study. Twenty-five patients had limited-type and 21 patients had diffuse-type scleroderma. Only left eyes of the patients and control subjects were used in the analysis. Demographic features of all the patients and control subjects were recorded. Each subject underwent ophthalmological examinations including refraction, visual acuity, intraocular pressure, axial length (AXL) measurement, slit-lamp biomicroscopy, and fundus examination. Body mass index (BMI) was estimated for all participants. Results There were no significant differences between the patients with scleroderma and the control subjects in terms of age, gender, BMI, mean AXL, and mean spherical equivalent refractive error (SE) ( P =0.1, P =0.086, P =0.37, P =0.55, and P =0.072 respectively). The patients with scleroderma had significantly thinner nasal, temporal, and subfoveal choroid than the healthy control subjects ( P 1 =0.012, P 2 =0.046, and P 3 <0.001, respectively). There were no significant differences between the patients with limited-type and diffuse-type scleroderma in terms of age, gender, BMI, mean AXL, mean SE, nasal, temporal, and subfoveal choroidal thicknesses (all P >0.05). Conclusions Choroidal thickness in patients with scleroderma was significantly less than healthy control subjects. Vasculopathy in scleroderma is characterized by obliteration of arterioles and reduced capillary density may cause atrophy of choroid in patients with scleroderma.