Details

Autor(en) / Beteiligte

• Yeung, Kay
• Ruscoe, Rebecca E.
• Rae, James
• Pulis, Alexander P.
• Procter, David J.

Titel

Enantioselective Generation of Adjacent Stereocenters in a Copper-Catalyzed Three-Component Coupling of Imines, Allenes, and Diboranes

Ist Teil von

• Angewandte Chemie (International ed.), 2016-09, Vol.55 (39), p.11912-11916

Auflage

International ed. in English

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A highly enantio‐ and diastereoselective copper‐catalyzed three‐component coupling affords the first general synthesis of homoallylic amines bearing adjacent stereocenters from achiral starting materials. The method utilizes a commercially available NHC ligand and copper source, operates at ambient temperature, couples readily available simple imines, allenes, and diboranes, and yields high‐value homoallylic amines that exhibit versatile amino, alkenyl, and boryl units. A copper‐catalyzed three‐component coupling affords homoallylic amines with adjacent stereocenters from achiral starting materials with high enantio‐ and diastereoselectivity. The method utilizes a commercially available NHC ligand and copper source, operates at ambient temperature, couples simple imines, allenes, and diboranes, and yields valuable homoallylic amines with versatile amino, alkenyl, and boryl units.