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Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2016-07, Vol.171B (5), p.733-747
Brevik, Erlend J.
van Donkelaar, Marjolein M. J.
Weber, Heike
Sánchez-Mora, Cristina
Jacob, Christian
Rivero, Olga
Kittel-Schneider, Sarah
Garcia-Martínez, Iris
Aebi, Marcel
van Hulzen, Kimm
Cormand, Bru
Ramos-Quiroga, Josep A.
Lesch, Klaus-Peter
Reif, Andreas
Ribasés, Marta
Franke, Barbara
Posserud, Maj-Britt
Johansson, Stefan
Lundervold, Astri J.
Haavik, Jan
Zayats, Tetyana
2016
Volltextzugriff (PDF)
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Autor(en) / Beteiligte
Brevik, Erlend J.
van Donkelaar, Marjolein M. J.
Weber, Heike
Sánchez-Mora, Cristina
Jacob, Christian
Rivero, Olga
Kittel-Schneider, Sarah
Garcia-Martínez, Iris
Aebi, Marcel
van Hulzen, Kimm
Cormand, Bru
Ramos-Quiroga, Josep A.
Lesch, Klaus-Peter
Reif, Andreas
Ribasés, Marta
Franke, Barbara
Posserud, Maj-Britt
Johansson, Stefan
Lundervold, Astri J.
Haavik, Jan
Zayats, Tetyana
Titel
Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder
Ist Teil von
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2016-07, Vol.171B (5), p.733-747
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome‐wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome‐wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome‐wide significance (P < 5.00E‐08). The strongest signal in aADHD was observed at rs10826548, within a long noncoding RNA gene (beta = −1.66, standard error (SE) = 0.34, P = 1.07E‐06), closely followed by rs35974940 in the neurotrimin gene (beta = 3.23, SE = 0.67, P = 1.26E‐06). The top GWA SNPs observed in aADHD showed significant enrichment of signals from both the defiant/vindictive dimension (Fisher's P‐value = 2.28E‐06) and the irritable dimension in cADHD (Fisher's P‐value = 0.0061). In sum, our results identify a number of biologically interesting markers possibly underlying childhood aggressiveness and provide targets for further genetic exploration of aggressiveness across psychiatric disorders. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4841
eISSN: 1552-485X
DOI: 10.1002/ajmg.b.32434
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5071721
Format
–
Schlagworte
ADHD
,
Adolescent
,
Adult
,
aggression
,
Aggression - physiology
,
Aggression - psychology
,
Attention Deficit Disorder with Hyperactivity - complications
,
Attention Deficit Disorder with Hyperactivity - genetics
,
Attention Deficit Disorder with Hyperactivity - psychology
,
Child
,
Female
,
Genetic Predisposition to Disease
,
Genetics
,
Genome-Wide Association Study - methods
,
GWAS
,
Humans
,
Male
,
Polymorphism, Single Nucleotide - genetics
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