Details

Autor(en) / Beteiligte

• Businaro, Rita
• Corsi, Mariangela
• Di Raimo, Tania
• Marasco, Sergio
• Laskin, Debra L.
• Salvati, Bruno
• Capoano, Raffaele
• Ricci, Serafino
• Siciliano, Camilla
• Frati, Giacomo
• De Falco, Elena

Titel

Multidisciplinary approaches to stimulate wound healing

Ist Teil von

• Annals of the New York Academy of Sciences, 2016-08, Vol.1378 (1), p.137-142

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• New civil wars and waves of terrorism are causing crucial social changes, with consequences in all fields, including health care. In particular, skin injuries are evolving as an epidemic issue. From a physiological standpoint, although wound repair takes place more rapidly in the skin than in other tissues, it is still a complex organ to reconstruct. Genetic and clinical variables, such as diabetes, smoking, and inflammatory/immunological pathologies, are also important risk factors limiting the regenerative potential of many therapeutic applications. Therefore, optimization of current clinical strategies is critical. Here, we summarize the current state of the field by focusing on stem cell therapy applications in wound healing, with an emphasis on current clinical approaches being developed. These involve protocols for the ex vivo expansion of adipose tissue–derived mesenchymal stem cells by means of a patented Good Manufacturing Practice–compliant platelet lysate. Combinations of multiple strategies, including genetic modifications and stem cells, biomimetic scaffolds, and novel vehicles, such as nanoparticles, are also discussed as future approaches.