Details

Autor(en) / Beteiligte

• Ironside, Alastair J
• Jones, J Louise

Titel

Stromal characteristics may hold the key to mammographic density: the evidence to date

Ist Teil von

• Oncotarget, 2016-05, Vol.7 (21), p.31550-31562

Ort / Verlag

United States: Impact Journals LLC

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• There is strong epidemiological data indicating a role for increased mammographic density (MD) in predisposing to breast cancer, however, the biological mechanisms underlying this phenomenon are less well understood. Recently, studies of human breast tissues have started to characterise the features of mammographically dense breasts, and a number of in-vitro and in-vivo studies have explored the potential mechanisms through which dense breast tissue may exert this tumourigenic risk. This article aims to review both the pathological and biological evidence implicating a key role for the breast stromal compartment in MD, how this may be modified and the clinical significance of these findings. The epidemiological context will be briefly discussed but will not be covered in detail.