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Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis
Hippocampus, 2016-02, Vol.26 (2), p.261-271
Garthe, Alexander
Roeder, Ingo
Kempermann, Gerd
2016
Details
Autor(en) / Beteiligte
Garthe, Alexander
Roeder, Ingo
Kempermann, Gerd
Titel
Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis
Ist Teil von
Hippocampus, 2016-02, Vol.26 (2), p.261-271
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
ABSTRACT We here show that living in a stimulus‐rich environment (ENR) improves water maze learning with respect to specific key indicators that in previous loss‐of‐function experiments have been shown to rely on adult hippocampal neurogenesis. Analyzing the strategies employed by mice to locate the hidden platform in the water maze revealed that ENR facilitated task acquisition by increasing the probability to use effective search strategies. ENR also enhanced the animals’ behavioral flexibility, when the escape platform was moved to a new location. Treatment with temozolomide, which is known to reduce adult neurogenesis, abolished the effects of ENR on both acquisition and flexibility, while leaving other aspects of water maze learning untouched. These characteristic effects and interdependencies were not seen in parallel experiments with voluntary wheel running (RUN), a second pro‐neurogenic behavioral stimulus. Since the histological assessment of adult neurogenesis is by necessity an end‐point measure, the levels of neurogenesis over the course of the experiment can only be inferred and the present study focused on behavioral parameters as analytical endpoints. Although the correlation of physical activity with precursor cell proliferation and of learning and the survival of new neurons is well established, how the specific functional effects described here relate to dynamic changes in the stem cell niche remains to be addressed. Nevertheless, our findings support the hypothesis that adult neurogenesis is a critical mechanism underlying the beneficial effects of leading an active live, rich in experiences. © 2015 The Authors Hippocampus Published by Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1050-9631
eISSN: 1098-1063
DOI: 10.1002/hipo.22520
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5049654
Format
–
Schlagworte
Age Factors
,
Animals
,
Environment
,
environmental enrichment
,
exercise
,
Female
,
hippocampus
,
Hippocampus - cytology
,
Hippocampus - physiology
,
Learning - physiology
,
Maze Learning - physiology
,
memory
,
Mice
,
Mice, Inbred C57BL
,
Neurogenesis - physiology
,
plasticity
,
stem cells
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