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Parental risk factors for oral clefts among Central Africans, Southeast Asians, and Central Americans
Birth defects research. A Clinical and molecular teratology, 2015-10, Vol.103 (10), p.863-879
Figueiredo, Jane C.
Ly, Stephanie
Magee, Kathleen S.
Ihenacho, Ugonna
Baurley, James W.
Sanchez-Lara, Pedro A.
Brindopke, Frederick
Nguyen, Thi-Hai-Duc
Nguyen, Viet
Tangco, Maria Irene
Giron, Melissa
Abrahams, Tamlin
Jang, Grace
Vu, Annie
Zolfaghari, Emily
Yao, Caroline A.
Foong, Athena
DeClerk, Yves A.
Samet, Jonathan M.
Magee III, William
2015
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Figueiredo, Jane C.
Ly, Stephanie
Magee, Kathleen S.
Ihenacho, Ugonna
Baurley, James W.
Sanchez-Lara, Pedro A.
Brindopke, Frederick
Nguyen, Thi-Hai-Duc
Nguyen, Viet
Tangco, Maria Irene
Giron, Melissa
Abrahams, Tamlin
Jang, Grace
Vu, Annie
Zolfaghari, Emily
Yao, Caroline A.
Foong, Athena
DeClerk, Yves A.
Samet, Jonathan M.
Magee III, William
Titel
Parental risk factors for oral clefts among Central Africans, Southeast Asians, and Central Americans
Ist Teil von
Birth defects research. A Clinical and molecular teratology, 2015-10, Vol.103 (10), p.863-879
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Background Several lifestyle and environmental exposures have been suspected as risk factors for oral clefts, although few have been convincingly demonstrated. Studies across global diverse populations could offer additional insight given varying types and levels of exposures. Methods We performed an international case–control study in the Democratic Republic of the Congo (133 cases, 301 controls), Vietnam (75 cases, 158 controls), the Philippines (102 cases, 152 controls), and Honduras (120 cases, 143 controls). Mothers were recruited from hospitals and their exposures were collected from interviewer‐administered questionnaires. We used logistic regression modeling to estimate odds ratios (OR) and 95% confidence intervals (CI). Results Family history of clefts was strongly associated with increased risk (maternal: OR = 4.7; 95% CI, 3.0–7.2; paternal: OR = 10.5; 95% CI, 5.9–18.8; siblings: OR = 5.3; 95% CI, 1.4–19.9). Advanced maternal age (5 year OR = 1.2; 95% CI, 1.0–1.3), pregestational hypertension (OR = 2.6; 95% CI, 1.3–5.1), and gestational seizures (OR = 2.9; 95% CI, 1.1–7.4) were statistically significant risk factors. Lower maternal (secondary school OR = 1.6; 95% CI, 1.2–2.2; primary school OR = 2.4, 95% CI, 1.6–2.8) and paternal education (OR = 1.9; 95% CI, 1.4–2.5; and OR = 1.8; 95% CI, 1.1–2.9, respectively) and paternal tobacco smoking (OR = 1.5, 95% CI, 1.1–1.9) were associated with an increased risk. No other significant associations between maternal and paternal factors were found; some environmental factors including rural residency, indoor cooking with wood, chemicals and water source appeared to be associated with an increased risk in adjusted models. Conclusion Our study represents one of the first international studies investigating risk factors for clefts among multiethnic underserved populations. Our findings suggest a multifactorial etiology including both maternal and paternal factors. Birth Defects Research (Part A) 103:863–879, 2015. © 2015 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1542-0752
eISSN: 1542-0760
DOI: 10.1002/bdra.23417
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5049483
Format
–
Schlagworte
Adult
,
Africa, Central
,
Asia, Southeastern
,
Asian Continental Ancestry Group
,
Case-Control Studies
,
Central America
,
Child, Preschool
,
cleft lip/palate
,
cleft palate
,
Cleft Palate - epidemiology
,
Cleft Palate - etiology
,
Female
,
Humans
,
Indians, Central American
,
Indians, South American
,
Infant
,
Infant, Newborn
,
Male
,
maternal health
,
Models, Biological
,
multiethnic populations
,
parental risk factors
,
Risk Factors
,
Socioeconomic Factors
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