Details

Autor(en) / Beteiligte

• Wu, Guo-Qing
• Chai, Ke-Qun
• Zhu, Xiu-Ming
• Jiang, Hua
• Wang, Xiao
• Xue, Qian
• Zheng, Ai-Hong
• Zhou, Hong-Ying
• Chen, Yun
• Chen, Xiao-Chen
• Xiao, Jian-Yong
• Ying, Xu-Hua
• Wang, Fu-Wei
• Rui, Tao
• Liao, Yi-Ji
• Xie, Dan
• Lu, Li-Qin
• Huang, Dong-Sheng

Titel

Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

Ist Teil von

• Oncotarget, 2016-05, Vol.7 (18), p.26535-26550

Ort / Verlag

United States: Impact Journals LLC

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Curcumin is potentially therapeutic for malignant diseases. The mechanisms of this effect might involve a combination of antioxidant, immunomodulatory, proapoptotic, and antiangiogenic activities. However, the exact mechanisms are not fully understood. In the present study, we provided evidences that curcumin suppressed the expression of enhancer of zeste homolog 2 (EZH2) in lung cancer cells both transcriptionally and post-transcriptionally. Curcumin inhibited the expression of EZH2 through microRNA (miR)-let 7c and miR-101. Curcumin decreased the expression of NOTCH1 through the inhibition of EZH2. There was a reciprocal regulation between EZH2 and NOTCH1 in lung cancer cells. These observations suggest that curcumin inhibits lung cancer growth and metastasis at least partly through the inhibition of EZH2 and NOTCH1.