Details
- Autor(en) / Beteiligte
- Titel
- Radiogenomics: a systems biology approach to understanding genetic risk factors for radiotherapy toxicity ?
- Ist Teil von
- Cancer letters, 2016-11, Vol.382 (1), p.95-109
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Different pathways are involved in normal-tissue reaction after radiotherapy • Combining different ‘omics’ techniques may identify critical pathways • Functional assays may identify patient subgroups with different mechanisms • A systems biology approach promises synergy from ‘omics’ and functional assays
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2016.02.035Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5016239
- Format
- –
- Schlagworte
- Apoptosis, Cancer, Cancer therapies, Cell adhesion & migration, Cell division, Cytokines, Gene expression microarrays, Gene Expression Profiling, Genetic Markers, Genetic Predisposition to Disease, Genome-wide association studies, Genome-Wide Association Study, Genomics - methods, Hematology, Oncology and Palliative Medicine, Humans, Normal-tissue reaction, Phenotype, Polymorphism, Single Nucleotide, Predictive tests, Prostate, Proteomics - methods, Radiation Dosage, Radiation Exposure - adverse effects, Radiation Injuries - genetics, Radiation Injuries - metabolism, Radiation therapy, Radiotherapy, Radiotherapy - adverse effects, Risk Assessment, Risk Factors, Single-nucleotide polymorphisms, Stem cells, Systems Biology - methods, Systems Integration, Toxicity