Details

Autor(en) / Beteiligte

• Reed, Galen D
• von Morze, Cornelius
• Verkman, Alan S
• Koelsch, Bertram L
• Chaumeil, Myriam M
• Lustig, Michael
• Ronen, Sabrina M
• Bok, Robert A
• Sands, Jeff M
• Larson, Peder E Z
• Wang, Zhen J
• Larsen, Jan Henrik Ardenkjær
• Kurhanewicz, John
• Vigneron, Daniel B

Titel

Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry

Ist Teil von

• Tomography (Ann Arbor), 2016-06, Vol.2 (2), p.125-137

Ort / Verlag

United States: Grapho Publications, LLC

Erscheinungsjahr

2016

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• spin spin relaxation time ( ) heterogeneity of hyperpolarized [ C, N ]urea in the rat kidney was investigated. Selective quenching of the vascular hyperpolarized C signal with a macromolecular relaxation agent revealed that a long- component of the [ C, N ]urea signal originated from the renal extravascular space, thus allowing the vascular and renal filtrate contrast agent pools of the [ C, N ]urea to be distinguished via multi-exponential analysis. The response to induced diuresis and antidiuresis was performed with two imaging agents: hyperpolarized [ C, N ]urea and a control agent hyperpolarized bis-1,1-(hydroxymethyl)-1- C-cyclopropane- H . Large increases in the inner-medullar and papilla were observed with the former agent and not the latter during antidiuresis. Therefore, [ C, N ]urea relaxometry is sensitive to two steps of the renal urea handling process: glomerular filtration and the inner-medullary urea transporter (UT)-A1 and UT-A3 mediated urea concentrating process. Simple motion correction and subspace denoising algorithms are presented to aid in the multi exponential data analysis. Furthermore, a -edited, ultra long echo time sequence was developed for sub-2 mm resolution 3D encoding of urea by exploiting relaxation differences in the vascular and filtrate pools.