Angewandte Chemie (International ed.), 2012-02, Vol.51 (8), p.1840-1843
2012
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- Autor(en) / Beteiligte
- Titel
- Water-Soluble, Donor-Acceptor Biphenyl Derivatives in the 2-(o-Nitrophenyl)propyl Series: Highly Efficient Two-Photon Uncaging of the Neurotransmitter γ-Aminobutyric Acid at λ=800 nm
- Ist Teil von
- Angewandte Chemie (International ed.), 2012-02, Vol.51 (8), p.1840-1843
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Rattling the cage: The two γ‐aminobutyric acid (GABA) derivatives 1 and 2 exhibit efficient and rapid (<5×10−6 s) GABA photorelease upon one‐photon excitation combined with two‐photon uncaging cross‐section at λ=800 nm. Compounds 1 and 2 were successfully used for two‐photon GABA release in intact brain tissue, thus offering attractive perspectives in chemical neurosciences.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.201106559Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4977189
- Format
- –
- Schlagworte
- Animals, biaryls, Biochemistry, Molecular Biology, Biphenyl Compounds - chemistry, Brain Chemistry, caged compounds, Cellular Biology, gamma-Aminobutyric Acid - chemistry, gamma-Aminobutyric Acid - metabolism, Life Sciences, Neurotransmitter Agents - chemistry, Neurotransmitter Agents - metabolism, neurotransmitters, Patch-Clamp Techniques, Photochemical Processes, Photolysis, Photons, Pyramidal Cells - chemistry, Pyramidal Cells - metabolism, Rats, Spectrophotometry, Ultraviolet - methods, synthetic methods