Immunotherapy, 2015-11, Vol.7 (11), p.1187-1199
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Targeting B-cell maturation antigen in multiple myeloma
- Ist Teil von
- Immunotherapy, 2015-11, Vol.7 (11), p.1187-1199
- Ort / Verlag
- England: Future Medicine Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Novel effective immunotherapies are needed for patients with multiple myeloma (MM), since disease recurrence remains a major obstacle. B-cell maturation antigen (BCMA), a cell surface protein universally expressed on malignant plasma cells , has emerged as a very selective antigen to be targeted in novel treatments for MM. We here first review BCMA-related biology, and then highlight the recent clinical development of a novel afucosylated anti-BCMA monoclonal antibody conjugated with monomethyl auristatin F via noncleavable linker (GSK2857916). Chimeric antigen receptor-expressing T cells targeting BCMA may also induce specific and durable anti-MM responses by patients' own effector cells. Clinical trials testing these two approaches (NCT02064387, NCT02215967) are currently ongoing in relapsed and refractory MM patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1750-743XeISSN: 1750-7448DOI: 10.2217/imt.15.77Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4976846
- Format
- –
- Schlagworte
- ADC, Animals, Antibodies, Monoclonal - chemistry, Antibodies, Monoclonal - therapeutic use, antibody drug conjugate, Antigens, Antigens, Neoplasm - immunology, Antigens, Neoplasm - metabolism, Apoptosis, B-cell maturation antigen, B-Cell Maturation Antigen - immunology, B-Cell Maturation Antigen - metabolism, BCMA, Binding sites, BM, Bone marrow, Cancer therapies, CAR-expressing T cells, CAR-T, Cell growth, Cell surface, chimeric antigen receptor, Chimeric antigen receptors, Clinical trials, Clinical Trials as Topic, Cytokines, Cytotoxicity, Disease, Effector cells, Fc-engineered therapeutic antibody, Heparan sulfate, Humans, Immunotherapy, Leukemia, Ligands, Lymphocytes B, Lymphocytes T, Maturation, Melanoma, microenvironment, MM, Molecular Targeted Therapy, Monoclonal antibodies, Multiple myeloma, Multiple Myeloma - immunology, Multiple Myeloma - therapy, Oligopeptides - chemistry, Patients, Plasma, Plasma cells, Protein Engineering, Receptors, Antigen, T-Cell - genetics, Recombinant Fusion Proteins - genetics, Review, T-Lymphocytes - immunology, T-Lymphocytes - transplantation, targeted immunotherapy