Nutrition journal, 2016-08, Vol.15 (1), p.72-72, Article 72
2016
Details
- Autor(en) / Beteiligte
- Titel
- Role of bioactive fatty acids in nonalcoholic fatty liver disease
- Ist Teil von
- Nutrition journal, 2016-08, Vol.15 (1), p.72-72, Article 72
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human and murine models. In contrast, polyunsaturated fatty acids exhibit antiobesity, anti steatosic and anti-inflammatory effects. The combination of these forms of fatty acids-according to dietary type, daily intake and the proportion of n-6 to n-3 fats-can compromise hepatic lipid metabolism. A chemosensory rather than a nutritional role makes bioactive fatty acids possible biomarkers for NAFLD. Bioactive fatty acids provide health benefits through modification of fatty acid composition and modulating the activity of liver cells during liver fibrosis. More and better evidence is necessary to elucidate the role of bioactive fatty acids in nutritional and clinical treatment strategies for patients with NAFLD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1475-2891eISSN: 1475-2891DOI: 10.1186/s12937-016-0191-8Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4970250
- Format
- –
- Schlagworte
- Diet, Dietary Fats - administration & dosage, Dietary Fats - adverse effects, Dietary Fats - classification, Fatty acids, Fatty Acids - administration & dosage, Fatty Acids - classification, Fatty Acids - physiology, Fatty Acids, Monounsaturated, Fatty Acids, Omega-3, Fatty Acids, Omega-6, Fatty Acids, Unsaturated, Fatty liver, Health aspects, Humans, Lipid metabolism, Lipid Metabolism - drug effects, Liver - metabolism, Liver Cirrhosis, Non-alcoholic Fatty Liver Disease - physiopathology, Nutritional aspects, Physiological aspects, Review, Risk factors