Details

Autor(en) / Beteiligte

• Ide, Tetsuya
• Moriyama, Akiko
• Uchida, Kazuyuki
• Chambers, James K.
• Okazaki, Takanobu
• Kobayashi, Kinji
• Nakatsuji, Shunji
• Matsumoto, Masahiro

Titel

Neuroblastoma at the trigeminal nerve in a cynomolgus monkey (Macaca fascicularis)

Ist Teil von

• Journal of Toxicologic Pathology, 2016, Vol.29(3), pp.191-194

Ort / Verlag

Japan: JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

Erscheinungsjahr

2016

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• A male cynomolgus monkey (Macaca fascicularis) of 5 years and 11 months of age from the vehicle control group of a 4-week repeated oral dose toxicity study had a spontaneously occurring mass lesion directly attached to the proximal part of the left trigeminal nerve. Histologically, the mass was characterized by a multifocal nodular appearance. Nodular zones showed low to moderate cellularity and were composed of small round cells exhibiting nuclear uniformity. On the other hand, inter-nodular zones were composed of nerve fiber containing septa and closely aggregated highly pleomorphic cells. Immunohistochemically, the small round cells were strongly immunopositive for synaptophysin, neuN, and class III beta-tubulin, while the highly pleomorphic cells were weakly immunopositive for neuN and occasionally immunopositive for class III beta-tubulin and doublecortin, suggesting that the tumor had originated from a neuronal lineage cell. Based on these findings, the mass was diagnosed as a neuroblastoma at the trigeminal nerve.