Details

Autor(en) / Beteiligte

• Xu, Ming-Ming
• Ren, Wen-Ming
• Tang, Xi-Can
• Hu, You-Hong
• Zhang, Hai-Yan

Titel

Advances in development of fluorescent probes for detecting amyloid-β aggregates

Ist Teil von

• Acta pharmacologica Sinica, 2016-06, Vol.37 (6), p.719-730

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• With accumulating evidence suggesting that amyloid-β （Aβ） deposition is a good diagnostic biomarker for Alzheimer＇s disease （AD）, the discovery of active Aβ probes has become an active area of research. Among the existing imaging methods, optical imaging targeting Aβ aggregates （fibrils or oligomers）, especially using near-infrared （NIR） fluorescent probes, is increasingly recognized as a promising approach for the early diagnosis of AD due to its real time detection, low cost, lack of radioactive exposure and high-resolution. In the past decade, a variety of fluorescent probes have been developed and tested for efficiency in vitro, and several probes have shown efficacy in AD transgenic mice. This review classifies these representative probes based on their chemical structures and functional modes （dominant solvent-dependent mode and a novel solvent-independent mode）. Moreover, the pharmaceutical characteristics of these representative probes are summarized and discussed. This review provides important perspectives for the future development of novel NIR Aβ diagnostic probes.