Details

Autor(en) / Beteiligte

• Spadaro, Melania
• Gerdes, Lisa Ann
• Krumbholz, Markus
• Ertl-Wagner, Birgit
• Thaler, Franziska Sabrina
• Schuh, Elisabeth
• Metz, Imke
• Blaschek, Astrid
• Dick, Andrea
• Brück, Wolfgang
• Hohlfeld, Reinhard
• Meinl, Edgar
• Kümpfel, Tania

Titel

Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis

Ist Teil von

• Neurology : neuroimmunology & neuroinflammation, 2016-10, Vol.3 (5), p.e257-e257

Ort / Verlag

United States: American Academy of Neurology

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Freely accessible e-journals

Beschreibungen/Notizen

• OBJECTIVES:To evaluate the presence of antibodies to conformation-intact myelin oligodendrocyte glycoprotein (MOG) in a subgroup of adult patients with clinically definite multiple sclerosis (MS) preselected for a specific clinical phenotype including severe spinal cord, optic nerve, and brainstem involvement. METHODS:Antibodies to MOG were investigated using a cell-based assay in 3 groups of patients104 preselected patients with MS (group 1), 55 age- and sex-matched, otherwise unselected patients with MS (group 2), and in 22 brain-biopsied patients with demyelinating diseases of the CNS (n = 19 with MS), 4 of whom classified as MS type II (group 3). Recognized epitopes were identified with mutated variants of MOG. RESULTS:Antibodies to MOG were found in about 5% (5/104) of preselected adult patients with MS. In contrast, in groups 2 and 3, none of the patients tested positive for MOG antibodies. Patients with MS with antibodies to MOG predominantly manifested with concomitant severe brainstem and spinal cord involvement and had a severe disease course with high relapse rates and failure to several disease-modifying therapies. Three of them had been treated with plasma exchange with a favorable response. All anti-MOG–positive patients with MS showed typical MS lesions on brain MRI. Longitudinal analysis up to 9 years revealed fluctuations and reappearance of anti-MOG reactivity. Epitope mapping indicated interindividual heterogeneity, yet intraindividual stability of the antibody response. CONCLUSIONS:Antibodies to MOG can be found in a distinct subgroup of adult MS with a specific clinical phenotype and may indicate disease heterogeneity.