Details

Autor(en) / Beteiligte

• Kohn, Todd J
• Du, Xiaohui
• Lai, SuJen
• Xiong, YuMei
• Komorowski, Renee
• Veniant, Murielle
• Fu, Zice
• Jiao, Xianyun
• Pattaropong, Vatee
• Chow, David
• Cardozo, Mario
• Jin, Lixia
• Conn, Marion
• DeWolf, Walter E
• Kraser, Christopher F
• Hinklin, Ronald J
• Boys, Mark L
• Medina, Julio C
• Houze, Jonathan
• Dransfield, Paul
• Coward, Peter

Titel

5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

Ist Teil von

• ACS medicinal chemistry letters, 2016-07, Vol.7 (7), p.666-670

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Two 1-(4-aryl-5-alkyl-pyridin-2-yl)-3-methylurea glucokinase activators were identified with robust in vivo efficacy. These two compounds possessed higher solubilities than the previously identified triaryl compounds (i.e., AM-2394). Structure–activity relationship studies are presented along with relevant pharmacokinetic and in vivo data.