Details

Autor(en) / Beteiligte

• Huang, Jinling
• Meng, Shaoshuai
• Hong, Shanjuan
• Lin, Xin
• Jin, Wei
• Dong, Chen

Titel

IL-17C is required for lethal inflammation during systemic fungal infection

Ist Teil von

• Cellular & molecular immunology, 2016-07, Vol.13 (4), p.474-483

Ort / Verlag

China: Nature Publishing Group

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Within the interleukin-17 （IL-17） family of cytokines, IL-17A is known to be critical in the host defense against fungal infections; however, the function of the other IL-17 family members in anti-fungal immunity remains largely unknown. Here, we show that IL-17C expression was highly induced in kidney epithelial cells after fungal infection. Mice that lacked IL-17C exhibited increased survival and attenuated kidney tissue damage, although they had similar fungal loads. IL-17C deficiency resulted in decreased pro-inflammatory cytokine expression compared with wild-type control mice. Additionally, IL-17C directly acted on renal epithelial cells in vitro to promote pro-inflammatory cytokine production. Taken together, our data demonstrate that IL-17C is a critical factor that potentiates inflammatory responses and causes host injury during fungal infection.