Details

Autor(en) / Beteiligte

• Zatsepin, Timofei S
• Kotelevtsev, Yuri V
• Koteliansky, Victor

Titel

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside

Ist Teil von

• International Journal of Nanomedicine, 2016-01, Vol.11, p.3077-3086

Ort / Verlag

New Zealand: Dove Medical Press Limited

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• This review covers the basic aspects of small interfering RNA delivery by lipid nano-particles (LNPs) and elaborates on the current status of clinical trials for these systems. We briefly describe the roles of all LNP components and possible strategies for their improvement. We also focus on the current clinical trials using LNP-formulated RNA and the possible outcomes for therapy in the near future. Also, we present a critical analysis of selected clinical trials that reveals the common logic behind target selection. We address this review to a wide audience, especially to medical doctors who are interested in the application of RNA interference-based treatment platforms. We anticipate that this review may spark interest in this particular audience and generate new ideas in target selection for the disorders they are dealing with.