Details

Autor(en) / Beteiligte

• Williams, Erika K.
• Chang, Rui B.
• Strochlic, David E.
• Umans, Benjamin D.
• Lowell, Bradford B.
• Liberles, Stephen D.

Titel

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

Ist Teil von

• Cell, 2016-06, Vol.166 (1), p.209-221

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormones and organ distension. Here, we investigate the molecular diversity of vagal sensory neurons and their roles in sensing gastrointestinal inputs. Genetic approaches allowed targeted investigation of gut-to-brain afferents involved in homeostatic responses to ingested nutrients (GPR65 neurons) and mechanical distension of the stomach and intestine (GLP1R neurons). Optogenetics, in vivo ganglion imaging, and genetically guided anatomical mapping provide direct links between neuron identity, peripheral anatomy, central anatomy, conduction velocity, response properties in vitro and in vivo, and physiological function. These studies clarify the roles of vagal afferents in mediating particular gut hormone responses. Moreover, genetic control over gut-to-brain neurons provides a molecular framework for understanding neural control of gastrointestinal physiology. [Display omitted] •Genetic deconstruction of vagal afferent types that monitor and control digestion•GPR65 neurons target intestinal villi, detect nutrients, and control gut motility•GLP1R neurons form specialized terminals that detect stomach and intestine stretch•Coding of autonomic inputs in vagal ganglion and brainstem Two types of neurons sending signals from the gut to the brain control digestion. One densely innervates intestinal villi and detects food, while another targets stomach and intestinal muscle and senses stretch.