Details

Autor(en) / Beteiligte

• Paudyal, Sharad C
• You, Zhongsheng

Titel

Sharpening the ends for repair： mechanisms and regulation of DNA resection

Ist Teil von

• Acta biochimica et biophysica Sinica, 2016-07, Vol.48 (7), p.647-657

Ort / Verlag

China: Oxford University Press

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• DNA end resection is a key process in the cellular response to DNA double-strand break damage that is essential for genome maintenance and cell survival. Resection involves selective process- ing of 5＇ ends of broken DNA to generate ssDNA overhangs, which in turn control both DNA repair and checkpoint signaling. DNA resection is the first step in homologous recombination-mediated repair and a prerequisite for the activation of the ataxia telangiectasia mutated and Rad3-related （ATR）-dependent checkpoint that coordinates repair with cell cycle progression and other cellular processes. Resection occurs in a cell cycle-dependent manner and is regulated by multiple factors to ensure an optimal amount of ssDNA required for proper repair and genome stability. Here, we review the latest findings on the molecular mechanisms and regulation of the DNA end resection process and their implications for cancer formation and treatment.