Details

Autor(en) / Beteiligte

• Sharma, Deepika
• Kanneganti, Thirumala-Devi

Titel

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

Ist Teil von

• The Journal of cell biology, 2016-06, Vol.213 (6), p.617-629

Ort / Verlag

United States: Rockefeller University Press

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1β and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome.