Details

Autor(en) / Beteiligte

• George, Paul M.
• Steinberg, Gary K.

Titel

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments

Ist Teil von

• Neuron (Cambridge, Mass.), 2015-07, Vol.87 (2), p.297-309

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Stroke remains a leading cause of death and disability in the world. Over the past few decades our understanding of the pathophysiology of stroke has increased, but greater insight is required to advance the field of stroke recovery. Clinical treatments have improved in the acute time window, but long-term therapeutics remain limited. Complex neural circuits damaged by ischemia make restoration of function after stroke difficult. New therapeutic approaches, including cell transplantation or stimulation, focus on reestablishing these circuits through multiple mechanisms to improve circuit plasticity and remodeling. Other research targets intact networks to compensate for damaged regions. This review highlights several important mechanisms of stroke injury and describes emerging therapies aimed at improving clinical outcomes. Stroke continues to cause immense burdens on millions throughout the world. George and Steinberg discuss the growing understanding of stroke pathophysiology and the established and novel treatment methods being developed to combat this serious disease.