Details

Autor(en) / Beteiligte

• Wu, Kong-Yan
• Zuo, Guo-Long
• Li, Xiao-Feng
• Ye, Qing
• Deng, Yong-Qiang
• Huang, Xing-Yao
• Cao, Wu-Chun
• Qin, Cheng-Feng
• Luo, Zhen-Ge

Titel

Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice

Ist Teil von

• Cell research, 2016-06, Vol.26 (6), p.645-654

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The recent Zika virus （ZIKV） epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal （i.p.） injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial gila cells （RGs） of dorsal ventricular zone of the fetuses, the primary neural progenitors responsi- ble for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports l;he conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies.