Details

Autor(en) / Beteiligte

• Schmitz, Sandra U.
• Grote, Phillip
• Herrmann, Bernhard G.

Titel

Mechanisms of long noncoding RNA function in development and disease

Ist Teil von

• Cellular and molecular life sciences : CMLS, 2016-07, Vol.73 (13), p.2491-2509

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2016

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Since decades it has been known that non-protein-coding RNAs have important cellular functions. Deep sequencing recently facilitated the discovery of thousands of novel transcripts, now classified as long noncoding RNAs (lncRNAs), in many vertebrate and invertebrate species. LncRNAs are involved in a wide range of cellular mechanisms, from almost all aspects of gene expression to protein translation and stability. Recent findings implicate lncRNAs as key players of cellular differentiation, cell lineage choice, organogenesis and tissue homeostasis. Moreover, lncRNAs are involved in pathological conditions such as cancer and cardiovascular disease, and therefore provide novel biomarkers and pharmaceutical targets. Here we discuss examples illustrating the versatility of lncRNAs in gene control, development and differentiation, as well as in human disease.