Details

Autor(en) / Beteiligte

• Gan-Or, Ziv
• Mohsin, Noreen
• Girard, Simon L
• Montplaisir, Jacques Y
• Ambalavanan, Amirthagowri
• Strong, Stephanie
• Mallett, Victoria
• Laurent, Sandra B
• Bourassa, Cynthia V
• Boivin, Michel
• Langlois, Melanie
• Arnulf, Isabelle
• Högl, Birgit
• Frauscher, Birgit
• Monaca, Christelle
• Desautels, Alex
• Gagnon, Jean-François
• Postuma, Ronald B
• Dion, Patrick A
• Dauvilliers, Yves
• Dupre, Nicolas
• Alcalay, Roy N
• Rouleau, Guy A

Titel

The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder

Ist Teil von

• Neurobiology of aging, 2016-07, Vol.43, p.180.e7-180.e13

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

ScienceDirect journals Piacenza

Beschreibungen/Notizen

• Abstract The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency > 0.01. None of the common variants was associated with PD or RBD in the different regression models. In a meta-analysis with fixed-effect model, the p.R160W variant was associated with an increased risk for PD (odds ratio = 1.22, 95% confidence interval = 1.02–1.47, p  = 0.03) but with significant heterogeneity ( p  = 0.048). Removing one study that introduced the heterogeneity resulted in nonsignificant association (odds ratio = 1.11, 95% confidence interval, 0.92–1.35, p  = 0.27, heterogeneity p  = 0.57). Rare variants had similar frequencies in patients and controls (10.54% and 10.15%, respectively, p  = 0.75), and no cumulative effect of carrying more than one MC1R variant was found. The present study does not support a role for the MC1R p.R160W and other variants in susceptibility for PD or RBD.