Details

Autor(en) / Beteiligte

• Gerlinger, Marco
• Rowan, Andrew J
• Horswell, Stuart
• Larkin, James
• Endesfelder, David
• Gronroos, Eva
• Martinez, Pierre
• Matthews, Nicholas
• Stewart, Aengus
• Tarpey, Patrick
• Varela, Ignacio
• Phillimore, Benjamin
• Begum, Sharmin
• McDonald, Neil Q
• Butler, Adam
• Jones, David
• Raine, Keiran
• Latimer, Calli
• Santos, Claudio R
• Nohadani, Mahrokh
• Eklund, Aron C
• Spencer-Dene, Bradley
• Clark, Graham
• Pickering, Lisa
• Stamp, Gordon
• Gore, Martin
• Szallasi, Zoltan
• Downward, Julian
• Futreal, P. Andrew
• Swanton, Charles

Titel

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Ist Teil von

• The New England journal of medicine, 2012-03, Vol.366 (10), p.883-892

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Genetic analysis was applied to different regions of renal-cell cancers. The lesions noted in the tumor were not found in every sample, and regions of the tumor had different gene-expression patterns. This suggests that extrapolation from results of a single biopsy may be problematic. Large-scale sequencing analyses of solid cancers have identified extensive heterogeneity between individual tumors. 1 – 6 Genetic intratumor heterogeneity has also been shown 7 – 15 and can contribute to treatment failure and drug resistance. Intratumor heterogeneity may have important consequences for personalized-medicine approaches that commonly rely on single tumor-biopsy samples to portray tumor mutational landscapes. Studies comparing mutational profiles of primary tumors and associated metastatic lesions 16 , 17 or local recurrences 18 have provided evidence of intratumor heterogeneity at nucleotide resolution. Intratumor heterogeneity within primary tumors and associated metastatic sites has not been systematically characterized by next-generation sequencing. We applied exome sequencing, chromosome aberration analysis, . . .