Details

Autor(en) / Beteiligte

• Jaques, David A
• Bagetakou, Spyridoula
• L'Huillier, Arnaud G
• Bartoli, Andrea
• Vargas, Maria-Isabel
• Fluss, Joel
• Kaiser, Laurent

Titel

Herpes simplex encephalitis as a complication of neurosurgical procedures: report of 3 cases and review of the literature

Ist Teil von

• Virology journal, 2016-05, Vol.13 (83), p.83-83, Article 83

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2016

Quelle

SpringerLink

Beschreibungen/Notizen

• Herpes simplex virus (HSV) is the most common identified cause of focal encephalitis worldwide. However, postoperative HSV encephalitis (HSVE) is a rare complication of neurosurgical procedures and a significant clinical challenge We describe 3 cases of postoperative HSVE and review all published reports. A total of 23 cases were identified. Clinical heterogeneity represents a diagnostic challenge in the postoperative setting. Cerebral magnetic resonance imaging showed typical findings in a minority of patients only, whereas HSV-specific polymerase chain reaction on the cerebrospinal fluid proved to be a valuable test. The postoperative viral pathophysiology remains a subject of debate. The rate of adverse outcome is high and early antiviral treatment seems to be a strong predictor of clinical outcome. We recommend early empirical treatment for any patient presenting with post-neurosurgical lymphocytic meningo-encephalitis, and prophylactic antiviral treatment for patients with a history of previous HSVE who will undergo a neurosurgical procedure.