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Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine
Journal of bone and mineral research, 2012-06, Vol.27 (6), p.1231-1239
McCauley, Laurie K
Martin, T John
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
McCauley, Laurie K
Martin, T John
Titel
Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine
Ist Teil von
Journal of bone and mineral research, 2012-06, Vol.27 (6), p.1231-1239
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Twenty‐five years ago a “new” protein was identified from cancers that caused hypercalcemia. It was credited for its ability to mimic parathyroid hormone (PTH), and hence was termed parathyroid hormone‐related protein (PTHrP). Today it is recognized for its widespread distribution, its endocrine, paracrine, and intracrine modes of action driving numerous physiologic and pathologic conditions, and its central role in organogenesis. The multiple biological activities within a complex molecule with paracrine modulation of adjacent target cells present boundless possibilities. The protein structure of PTHrP has been traced, dissected, and deleted comprehensively and conditionally, yet numerous questions lurk in its past that will carry into the future. Issues of the variable segments of the protein, including the enigmatic nuclear localization sequence, are only recently being clarified. Aspects of PTHrP production and action in the menacing condition of cancer are emerging as dichotomies that may represent intended temporal actions of PTHrP. Relative to PTH, the hormone regulating calcium homeostasis, PTHrP “controls the show” locally at the PTH/PTHrP receptor throughout the body. Great strides have been made in our understanding of PTHrP actions, yet years of exciting investigation and discovery are imminent. © 2012 American Society for Bone and Mineral Research.
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.1617
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4871126
Format
–
Schlagworte
Animals
,
Biological and medical sciences
,
BONE
,
Calcium homeostasis
,
CARTILAGE
,
Cytokines - metabolism
,
Evolution, Molecular
,
Fundamental and applied biological sciences. Psychology
,
History, 20th Century
,
Humans
,
HYPERCALCEMIA
,
Neoplasms - metabolism
,
Organ Specificity
,
PARACRINE
,
Parathyroid Hormone-Related Protein - history
,
Parathyroid Hormone-Related Protein - metabolism
,
PTH
,
PTHrP
,
Skeleton and joints
,
Vertebrates: osteoarticular system, musculoskeletal system
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