Nature (London), 2016-02, Vol.530 (7588), p.51-56
2016
Details
- Autor(en) / Beteiligte
- Titel
- Persistent HIV-1 replication maintains the tissue reservoir during therapy
- Ist Teil von
- Nature (London), 2016-02, Vol.530 (7588), p.51-56
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in immune complexes, and viral persistence. Although combinations of antiretroviral drugs usually suppress viral replication and reduce viral RNA to undetectable levels in blood, it is unclear whether treatment fully suppresses viral replication in lymphoid tissue reservoirs. Here we show that virus evolution and trafficking between tissue compartments continues in patients with undetectable levels of virus in their bloodstream. We present a spatial and dynamic model of persistent viral replication and spread that indicates why the development of drug resistance is not a foregone conclusion under conditions in which drug concentrations are insufficient to completely block virus replication. These data provide new insights into the evolutionary and infection dynamics of the virus population within the host, revealing that HIV-1 can continue to replicate and replenish the viral reservoir despite potent antiretroviral therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/nature16933Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4865637
- Format
- –
- Schlagworte
- Analysis, Anti-HIV Agents - administration & dosage, Anti-HIV Agents - pharmacology, Anti-HIV Agents - therapeutic use, Antiretroviral drugs, Care and treatment, Carrier State - blood, Carrier State - drug therapy, Carrier State - virology, Development and progression, Drug resistance, Drug Resistance, Viral - drug effects, Haplotypes, Haplotypes - drug effects, Health aspects, Highly active antiretroviral therapy, HIV, HIV (Viruses), HIV infection, HIV Infections - blood, HIV Infections - drug therapy, HIV Infections - virology, HIV-1 - drug effects, HIV-1 - genetics, HIV-1 - growth & development, HIV-1 - isolation & purification, Human immunodeficiency virus, Humans, Infection, Infections, Lymph Nodes - drug effects, Lymph Nodes - virology, Lymphatic system, Models, Biological, Molecular Sequence Data, Patient outcomes, Phylogenetics, Phylogeny, Physiological aspects, Selection, Genetic - drug effects, Sequence Analysis, DNA, Spatio-Temporal Analysis, Time Factors, Tissues, Viral Load - drug effects, Virus Replication - drug effects