Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (11), p.2641-2644
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis of a stable and orally bioavailable englerin analogue
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (11), p.2641-2644
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- [Display omitted] Synthesis of analogues of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2016.04.016Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4862412
- Format
- –
- Schlagworte
- Administration, Oral, Animals, Antineoplastic Agents - administration & dosage, Antineoplastic Agents - chemistry, Antineoplastic Agents - pharmacology, Bioavailability, Biological Availability, Cancer, Cell Line, Tumor, Cell Proliferation - drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Englerins, Humans, Mice, Molecular Structure, Rats, Sesquiterpenes, Sesquiterpenes, Guaiane - administration & dosage, Sesquiterpenes, Guaiane - chemistry, Sesquiterpenes, Guaiane - pharmacology, Structure-Activity Relationship