Pain (Amsterdam), 2016-02, Vol.157 (2), p.418-428
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Role of adult hippocampal neurogenesis in persistent pain
- Ist Teil von
- Pain (Amsterdam), 2016-02, Vol.157 (2), p.418-428
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning and emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal memories. Yet, the role of AHN in development of persistent pain has remained unexplored. In this study, we test the influence of AHN in postinjury inflammatory and neuropathic persistent pain-like behaviors by manipulating neurogenesis: pharmacologically through intracerebroventricular infusion of the antimitotic AraC; ablation of AHN by x-irradiation; and using transgenic mice with increased or decreased AHN. Downregulating neurogenesis reversibly diminished or blocked persistent pain; oppositely, upregulating neurogenesis led to prolonged persistent pain. Moreover, we could dissociate negative mood from persistent pain. These results suggest that AHN-mediated hippocampal learning mechanisms are involved in the emergence of persistent pain.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3959eISSN: 1872-6623DOI: 10.1097/j.pain.0000000000000332Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4858177
- Format
- –
- Schlagworte
- Animals, Carrageenan - toxicity, Chronic Pain - drug therapy, Chronic Pain - etiology, Chronic Pain - pathology, Chronic Pain - physiopathology, Disease Models, Animal, Double-Blind Method, Exploratory Behavior - drug effects, Exploratory Behavior - physiology, Gene Expression Regulation - drug effects, Gene Expression Regulation - radiation effects, Glycoside Hydrolases - pharmacology, Hippocampus - physiopathology, Hyperalgesia - physiopathology, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microtubule-Associated Proteins - metabolism, Mood Disorders - etiology, Neurogenesis - drug effects, Neurogenesis - physiology, Neurogenesis - radiation effects, Neuropeptides - metabolism, Pain Measurement, Pain Threshold - physiology, Physical Stimulation - adverse effects, Sciatica, Swimming, X-Rays - adverse effects