Aging cell, 2016-06, Vol.15 (3), p.582-584
2016
Details
- Autor(en) / Beteiligte
- Titel
- Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
- Ist Teil von
- Aging cell, 2016-06, Vol.15 (3), p.582-584
- Ort / Verlag
- England: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- Summary Recent high‐profile studies report GDF11 to be a key circulating ‘anti‐aging’ factor. However, a screen of extracellular proteins attempting to identify factors with ‘anti‐aging’ phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm the reported activity of GDF11, similar to other laboratories offering conflicting data and describe our attempts to do so in this short take.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1474-9718eISSN: 1474-9726DOI: 10.1111/acel.12475Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4854912
- Format
- –
- Schlagworte
- aging, Analysis, Animals, Cell Count, Cellular Senescence - drug effects, GDF11, Growth Differentiation Factors - pharmacology, HEK293 Cells, Humans, Mice, Muscles, Musculoskeletal system, Recombinant Proteins - pharmacology, Satellite cell, Satellite Cells, Skeletal Muscle - cytology, Satellite Cells, Skeletal Muscle - drug effects, Satellite Cells, Skeletal Muscle - metabolism, Satellites, Short Take, Short Takes