Neuroscience, 2016-06, Vol.324, p.355-366
2016
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- Autor(en) / Beteiligte
- Titel
- Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus
- Ist Teil von
- Neuroscience, 2016-06, Vol.324, p.355-366
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • We use a rat model of third trimester-equivalent binge alcohol exposure. • We investigated microglia number and activation state in the neonatal hippocampus. • Both neonatal alcohol and intubation decreased microglial number in CA1 and dentate gyrus. • Neonatal alcohol decreased cell territory in CA1, CA3 and dentate gyrus due to increased microglia activation. • Alcohol increased expression of cytokines CCL4 and TGF-β, while alcohol and intubation both increased IL-1β, TNF-α and CD11b.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2016.03.033Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4838517
- Format
- –
- Schlagworte
- Animals, Animals, Newborn, Binge Drinking - complications, Binge Drinking - immunology, CD11b Antigen - metabolism, Cell Count, Central Nervous System Depressants - toxicity, cytokines, development, Disease Models, Animal, Ethanol - toxicity, FASD, Fetal Alcohol Spectrum Disorders - immunology, Fetal Alcohol Spectrum Disorders - pathology, Hippocampus - drug effects, Hippocampus - growth & development, Hippocampus - immunology, Hippocampus - pathology, Interleukin-1beta - metabolism, Male, Microglia - drug effects, Microglia - metabolism, Microglia - pathology, neuroimmune, Neurology, pro-inflammatory, Rats, Long-Evans, Transforming Growth Factor beta - metabolism, Tumor Necrosis Factor-alpha - metabolism